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| 10-DAB |
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10-Deacetyl Baccatin III or 10-DAB-III is a natural organic compound isolated from the Pacific
yew tree (Taxus) and related species.10-DAB III is a white to off white crystalline powder, insoluble in
water. |
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| Its chemical name 12-b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,
6,9,11-tetrahydroxy-4a,8,12,13-tetramethyl-7,11-methno-5H-cyclodeca(3,4) benz(1,2b)oxet-5-one and
molecular formula C29H36O10. |
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| 10-DAB-III is a crucial intermediate for Paclitaxel & Docitaxel, two of the best anticancer drugs. |
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| Source |
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| 10-DAB-III is extracted from the leaf of Taxus Baccata. |
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| Taxus baccata is a conifernative to western, central and southern Europe, northwest Africa, northern
Iran and southwest Asia. It is the tree originally known as yew, now commonly known as the
common yew or European yew |
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| It is a small to medium-sized evergreen tree, growing 10–20 meters with a trunk up to 2 meters . The
bark is thin, scaly brown, coming off in small flakes aligned with the stem. The leaves are lanceolate,
flat, dark green, 1–4 cm long and 2–3 millimeters broad, arranged spirally on the stem, but with the
leaf bases twisted to align the leaves in two flat rows either side of the stem, except on erect leading
shoots where the spiral arrangement is more obvious. |
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| Applications |
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| 10-Deacetyl Baccatin III is the starting material for making the latest essential life saving
anti-cancer drugs Docetaxel & Paclitaxel,which are well known clinically prescribed drugs for treatment
of cancer.
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