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| Chlorogenic acid |
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| Chlorogenic acid is an ester of caffeic acid and (-)-quinic acid. It is an important Lignin bio synthetic intermediate. Chlorogenic acid is light greenish yellow powder ,soluble in hot water. Its chemical formula is (1S,3R,4R,5R)-3-{[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxy cyclohexanecarboxylic acid and molecular formula is C16H18O9.
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| This compound, long known as an antioxidant, also slows down the release of glucose into the blood stream after a meal. |
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| Source |
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| Chlorogenic Acid extracted from the seeds of Coffea arabica. |
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| Coffea arabica plants grow in between 9 -12 m tall, and have an open branching system; the leaves are opposite, simple elliptic-ovate to oblong, glossy dark green. The flowers are white and grow in axillary clusters. The fruit is a drupe (commonly called a "berry") maturing bright red to purple and typically contain two seeds (the coffee 'bean'). |
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| Coffea arabica is a species of coffea originally indigenous to the mountains of Yemen in the Arabian Peninsula. It is also cultivated in the southwestern highlands of Ethiopia and southeastern Sudan. |
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| Pharmacology |
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| Chlorogenic acid derivatives are identified as novel, potent, and specific inhibitors of the hepatic glucose 6-phosphate translocase. Inhibition of the glucose 6-phosphate translocase leads to a decrease in hepatic glucose production, rendering chlorogenic acid derivatives as potential novel therapeutics in patients with Type 2 diabetes. |
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| Since free radicals are believed to play a role in the development of chronic diseases such as cardiovascular disease and cancer , the consumption of Chlorogenic Acid may protect against these diseases. |
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| Chlorogenic acid found in Green Coffee Extract promote fat loss by blocking gastric and pancreatic lipase. |
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| Therapeutic Applications |
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- Chlorogenic Acid is long known as an Antioxidant.
- Chlorogenic Acid contribute to the prevention of Type 2 Diabetes Mellitus.
- Chlorogenic Acid is also used for weight loss.
- Chlorogenic Acid may inhibit inflammation and thereby reduce the risk of cardiovascular disease and other inflammatory diseases in postmenopausal women.
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| Dosage |
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| Since green coffee bean extract typically contains about 30% chlorogenic acids, this works out to a dose of about 60 mg of chlorogenic acids daily. |
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