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| Hyoscine N-butyl bromide |
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Hyoscine N-butyl bromide is a derivative of hyoscine. It is white crystalline powder. Hyoscine N-butyl bromide chemical formula is 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenyl propoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b) and molecular formula is C21H30BrNO4.
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| Hyoscine N-butyl bromide is known for its antispasmodic action since 1951.Hyoscine N-butyl bromide is an anticholinergic agent,it exerts a specific antispasmodic action on the smooth muscle of the gastrointestinal ,biliary and urinary tracts. |
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| Source |
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| Hyoscine is extracted from the leaves of the Duboisia tree found mainly in Australia and further reaction convert it into Hyoscine N-butyl bromide. |
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| Duboisia (Corkwood Tree) is a genus of small perennial shrubs to trees about 14 m tall, with extremely light wood and a thick corky bark. There are four species; all occur in Australia, and one also occurs in New Caledonia. It has alternate, smooth, entire leaves, narrowed into a short leaf-stalk, which is articulated to the branches.
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| Pharmacology |
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| Hyoscine N-butyl bromide acts by inhibiting cholinergic transmission in the abdominal and pelvic parasympathetic ganglia, thus relieving spasm in the smooth muscles of gastrointestinal, biliary, urinary tract and female genital organs, especially the cervico-uterine plexus and thus aiding cervical dilatation. |
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| Its onset of action after intravenous dosing is 10 minutes, peak effect is seen at 20-60 minutes, and action lasts for two hours, with an elimination half life of 4.8 hours. |
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| Therapeutic Application |
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- Hyoscine n-Butylbromide relieve cramps or spasms of the stomach, intestines (gut) and bladder.
- It is useful in treating Irritable Bowel Syndrome (IBS) and similar conditions
- Hyoscine n-Butylbromide is used to relieve menstrual period pain
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| Dosage |
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| Typical dose is 10mg 3 times daily. Adult dose may be increased if required up to 20mg 4 times daily (max 80mg/day). |
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