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| Raubasine |
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| Raubasine, an indole alkaloid, also known as Ajmalicine. Raubasine is Yellowish crystalline powder, odorless & tasteless,soluble in Chloroform, slightly soluble in Acetone and Methanol, insoluble in water. Its chemical formula is (19alpha)-16,17-Didehydro-19 methyloxayohimban-16-carboxylic acid methyl ester and its molecular formula is C21H24N2O3. |
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| Raubasine is an alpha-1-blocking agent, and it may be considered as a cerebral anti-ischemic agent. |
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| Source |
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| Surya Pharmaceuticals extracted Raubasine from the Root of Vinca Rosea. |
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| Raubasine (A-yohimbine,Ajmalicine) is originally isolated from Rauwolfia serpentina by Popelak, Kaiser & Spingler (1953) and subsequently from Vinca rosea (Kohlmunzer & Krupinska, 1960). |
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| Catharanthus roseus (Madagascar Periwinkle) is a species of Catharanthus native and endemic to Madagascar. Synonyms include Vinca rosea , Ammocallis rosea, and Lochnera rosea. |
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| It is an evergreen shrub or herbaceous plant growing to 1 m tall. The leaves are oval to oblong, glossy green, hairless, with a pale midrib and a short petiole , they are arranged in opposite pairs. The flowers are white to dark pink with a darker red center, with a basal tube and a corolla with five petal-like lobes. The fruit is a pair of follicles. |
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| Pharmacology |
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| Raubasine prolongs the refraction phase of the heart through a blockade of Na+ channels. In addition, the action potential is prolonged and an increase of the depolarization threshold occurs. It has negative inotropic properties accomplished by a small decrease of the heart rate. Raubasine increase the amount of oxygen brought to the brain and neurosensory tissue, by increasing the oxygen content of arterial blood. |
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| Therapeutic Application |
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| Raubasine is a class Ia anti arrhythmic agent and used in the treatment of super ventricular and ventricular arrhythmia. It might also be useful for the patient of Myasthenia gravis.Raubasine is also indicated in conditions like Acromegaly (short-term treatment before pituitary surgery), Auditory acuity, Neurosensorial deficit, Tinnitus, Visual acuity. |
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| Dosage |
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| Raubasine is used along with the Almitrine (A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemo receptors located on the carotid bodies.)for the treatment of age-related cerebral disorders and functional rehabilitation after stroke;30mg Almitrine and 10mg Raubasine 1tablet bid |
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