|
| Thiocolchicoside |
 |
 |
| Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside extracted from the seeds of Gloriosa superba..Its Chemical name is N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-enzo[d]heptalen-7-yl] acetamide and molecular formula C27H33NO10S . |
|
| Thiocolchicoside is a Yellow crystalline Powder, soluble in water & alcohol. |
|
 |
|
| Source |
|
| Thiocolchicoside is extracted from the seeds of Gloriosa Superba. |
|
| Gloriosa is a genus of five or six species in the plant family Colchicaceae, from tropical Africa and Asia. They are tender, tuberous rooted deciduous perennials, adapted to summer rainfall with a dormant dry season. Their native range is Africa, Southeastern Asia and parts of Malaysia, but they are now widely cultivated. |
|
| Gloriosa superba is the national flower of Zimbabwe, former Rhodesia (where it is a protected plant). It is also the state flower of Tamilnadu state in India. |
|
| Pharmacology |
|
| Thiocolchicoside binds to GABA-A and strychnine sensitive glycine receptors. Thiocolchicoside acting as a GABA-A receptor antagonist, its myorelaxant effects could be exerted at the supra-spinal level, via complex regulatory mechanisms, although a glycinergic mechanism of action cannot be excluded. The characteristics of the interaction of Thiocolchicoside with GABA-A receptors are qualitatively and quantitatively shared by its main circulating metabolite, the glucuronidated Derivative. |
|
 |
|
| Thiocolchicoside is rapidly absorbed after oral administration, and metabolized into 3 main metabolites. The two main circulating forms were the Thiocolchicoside aglycon and the glucuronidated derivative of Thiocolchicoside, which is active. Thiocolchicoside is well tolerated oral administration for periods of up to 6 months. |
|
| Therapeutic Indications |
|
| It has a relaxant effect on skeletal muscle. It also has anti-inflammatory, analgesic and anesthetic actions. |
|
| Dosage & Administration |
|
| Thiocolchicoside is given by the oral & intramuscular route. Adult for Muscle Spasms : Initially 16 mg Daily , Oral and up to 8mg daily intramuscular. |
|
|
|
|
|
|
|